Ultrafine anaphase bridges
WebUltrafine anaphase bridges (UFBs) result from a defect in sister chromatid segregation during anaphase. They arise from particular DNA structures, mostly generated at specific … Web1 Jun 2014 · Ultra-fine DNA bridges (UFBs) are a recently identified class of mitotic DNA structures that cannot be visualized using conventional DNA staining methods (e.g. using …
Ultrafine anaphase bridges
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Web1 Jun 2024 · Although chromatin bridges and lagging chromatin are always pathological (generating aneuploidy or complex genomic rearrangements), the main subject of this article, the ultrafine anaphase bridges, might, in addition to potentially driving genomic instability, play critical roles for the maintenance of chromosome structure in rapidly ... Webuntil anaphase and give rise to a high frequency of UFBs that are decorated with PICH, BLM and RPA (Figure 2). They were termed homologous recombination ultrafine bridges (HR-UFBs) to dis-tinguish them from centromeric UFBs, replication stress-associated UFBs, and telomeric UFBs (Figure 1). In parallel with these studies, work from
Web18 Dec 2024 · We find that intermediates persist until mitosis and form a distinct class of anaphase bridges, which we term homologous recombination ultra-fine bridges (HR-UFBs). WebEventually, in mitosis, they can evolve into ultrafine anaphase bridges (UFBs) connecting sister chromatids, which can finally lead to chromosomal instability. In the following sections, we focus on CFSs as an example of the extraordinary processes that cells carry out in mitosis to resolve problems that originated during the previous S-phase, in order to …
WebNew insights into the formation and resolution of ultrafine anaphase bridges. Semin Cell Dev Biol (2011), 22(8): 906-12. Chan KL, Hickson ID. On the origins of ultra-fine anaphase … Web16 Jul 2015 · There are two types of sister-chromatid anaphase bridges: chromatin bridges, consequences of defective sister chromatid segregation , can be stained with conventional dyes, such as DAPI; and ultrafine anaphase bridges (UFBs), which cannot be stained with conventional DNA dyes or antibodies against histones [8, 9]. UFBs were discovered only …
WebMost DNA double-strand breaks (DSBs) in S- and G2-phase cells are repaired accurately by Rad51-dependent sister chromatid recombination. However, a minority give rise to gross …
Web7 Dec 2015 · Here we report that TRF2 overexpression results in replication stalling in duplex telomeric repeat tracts and the subsequent formation of telomeric ultrafine anaphase bridges (UFBs), ultimately... the saint of fire fightershttp://sro.sussex.ac.uk/id/eprint/82640/1/genes-10-00232.pdf the saint of fort washington 1993 free onlineWebWe show that loss of the structure-selective endonuclease GEN1 reduces CFS expression, leading to defects in MiDAS, ultrafine anaphase bridge formation, and DNA damage in the … the saint of bleecker streetWeb19 Jan 2024 · Although it inhibits the resolution of taz1Δ telomere entanglements, it promotes the resolution of non-telomeric ultrafine anaphase bridges at ≤20°C. We … the saint of fort washington torrentWeb2 Mar 2024 · More information: Nannan Kong et al, RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1, Cell Reports (2024). DOI: … the saint of forgivenessWebUltra-fine anaphase DNA bridges (UFBs) were discovered in our group over 10 years ago. They are nucleosome-free DNA threads that connect the separating sister DNA masses … the saint of fort washingtonWeb26 Apr 2012 · Centromeric ultrafine anaphase bridges are physiological DNA structures thought to contain unresolved DNA catenations between the centromeres separating during anaphase. BLM and PICH helicases colocalize at these ultrafine anaphase bridges and promote their resolution. the saint of fort washington full movie