WebApr 4, 2024 · YONDELIS ® can cause muscle problems that can be severe and lead to death. Tell your healthcare provider right away if you have severe muscle pain or … WebMar 5, 2024 · The review started after a clinical study (OVC-3006) investigating the use of Yondelis in patients with ovarian cancer was stopped ahead of time, because an interim analysis of the results showed that, overall, patients treated with Yondelis plus pegylated liposomal doxorubicin (PLD, another cancer medicine) did not live longer than patients …
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WebEine Übersicht aller Fach- und Gebrauchsinformationen von Janssen Cilag finden Sie hier. Besuchen Sie jetzt die Janssen Medical Cloud. WebMar 18, 2024 · YONDELIS (trabectedin) for injection is supplied as a sterile lyophilized white to off-white powder/cake in a single-dose vial. Each single-dose vial contains 1 mg of trabectedin, 27.2 mg potassium dihydrogen phosphate, 400 mg sucrose, and phosphoric acid and potassium hydroxide (for Ph adjustment to 3.6 – 4.2). top 50 housing associations uk
Trabectedin: Ecteinascidin 743, Ecteinascidin-743, ET 743, ET
WebOct 17, 2016 · Treatment of unresectable or metastatic liposarcoma or leiomyosarcoma in patients who have received prior therapy with an anthracycline-containing regimen. Designated an orphan drug by FDA for the treatment of soft tissue sarcoma. Efficacy determined based on investigator-assessed progression-free survival. Trabectedin … WebMay 19, 2003 · Yondelis will be administered intravenously (i.v.) via a central catheter (tube) into a central vein once a week (0.58 mg/m2 as a 3-hour infusion on Days 1, 8, and 15 of each 28-day treatment cycle) or once every 3 weeks (1.5 mg/m2 administered as a 24-hour infusion on Day 1 of every 21-day treatment cycle) until disease progression. WebModification of YONDELIS dose with the strong CYP3A inhibitors and strong CYP3A inducers is complicated by the: o YONDELIS dose level at the time of administration of strong CYP3A inhibitors and strong CYP3A inducers. The recommended YONDELIS dose of 1.5 mg/m2 can be reduced to 1.2 mg/m2 and then to 1 mg/m2, based on adverse events. top 50 housing associations