WebCTLA-4 antibody or CTLA4 (cytotoxic T-lymphocyte-associated protein 4), classified as CD152, is a protein receptor known to functions as an immune checkpoint which downregulates the immune system. CTLA4 is found on the surface of T cells, and acts as an “off” switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. WebMouse CTLA-4 antibodies with has blocking effect against CD80/CD86 binding with CTLA4 can serve as a great surrogate antibody in mouse model. Mouse CTLA-4 Antibody (MCT.F6), mAb, Mouse is produced from the hybridoma resulting from fusion of SP2/0 myeloma and B-lymphocytes obtained from mouse immunized with recombinant mouse …
CTLA-4 blockade drives loss of T - Nature
WebCytotoxic T-Lymphocyte Antigen 4 (CTLA-4) is a cell surface glycoprotein with a theoretical molecular weight of 24.6 kDa belonging to the immunoglobulin family. CTLA-4 is a negative regulator of T cell response … WebJan 22, 2024 · Conversely, pH-dependent anti-CTLA-4 antibodies, which dissociate from the target under acidic pH in endosomes, allow physiological CTLA-4 recycling, and reduce adverse effects. The mode of action of the pH-dependent anti-CTLA-4 antibodies is rather counterintuitive because CTLA-4 is a membrane antigen that needs to be inactivated on … binaxnow test kit price
PE anti-human CD152 CTLA-4 Antibody anti-CD152 - L3D10
WebCytotoxic T-lymphocyte antigen 4 (CTLA-4) is an immune checkpoint receptor that negatively regulates the immune response. Blocking CTLA-4 may directly restore T-cell activation, reverse regulatory T cell (Treg)-driven T-cell suppression, and lead to long-term antitumor immunity. Research is ongoing to further optimize CTLA-4 blockade. WebFlow Cytometry: The fluorochrome-labeled L3D10 antibody is useful for immunofluorescent staining and flow cytometric analysis to identify CTLA-4-producing cells within mixed cell populations. Note: For testing human soluble CTLA-4 in serum, plasma or cell culture supernatant, LEGEND MAX™ Human Soluble CTLA-4 ELISA Kit with Pre-coated Plates ... WebDescription. CD152, also known as Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4), is a 33 kD member of the immunoglobulin superfamily. It is transiently expressed on activated T cells. CTLA4 is expressed on the surface of helper T cells and transmits an … cyrrus corporate finance a.s