WebJan 4, 2013 · Macrophage-adipocyte interactions are beyond the focus of this review, but it should be mentioned that investigators are actively examining the influence of … To examine the role of IRF3 in adipogenesis, pre-adipocytes from WT and KO mice were isolated from both vWAT and sWAT for adipocyte differentiation. IRF3 expression and activation were found to be induced on day 5 after initiation of differentiation and greatly increased on days 7–9 (Fig. 3a). … See more To understand the role of IRF3 in metabolism, we fed C57BL/6 mice with a HFD for 8 and 16 weeks to examine the expression of IRF3. After HFD for 8 weeks, we … See more To examine the role of IRF3 in obesity, we compared the body weight of gender- and age-matched WT and IRF3 KO mice at various ages. From the age of 4 … See more Next, an ITT and GTT were performed on WT and KO mice and found that both male and female KO mice developed IR and glucose intolerance around the age … See more In addition to PPARγ-regulated adipogenesis genes, enriched expression of genes involved in TNFα receptor signaling, cytokine and cytokine receptor signaling, … See more
Single-cell sequencing of human white adipose tissue ... - Nature
WebDec 16, 2024 · The suppressive effects of flavonoids on macrophage-associated adipocyte inflammation in a differentiated murine preadipocyte cell line (3T3-L1) co-cultured with a murine macrophage cell line (RAW264.7) were evaluated. Extracellular lipid accumulation was investigated via Oil Red O staining. The expression levels of adipogenesis- and … WebDec 29, 2024 · Now, a new study shows that adipocytes transfer mitochondria to adipose tissue macrophages, and that this process is impaired in obesity. “Several studies show that mitochondria can be... news in coventry today
Macrophage and adipocyte interaction as a source of
WebAug 4, 2024 · The former (left) causes appearance of beige adipocytes even in denervated iWAT and is associated with a shift in macrophage polarization toward the alternatively … WebMar 17, 2024 · An excessive accumulation of lipid droplets in obese individuals leads to structural and functional changes in the adipose tissue, which manifest as adipocyte hypertrophy, increased recruitment of immunocompetent cells such as macrophages or lymphocytes, increase in the pro-inflammatory activity and release of cytokines such as … WebApr 27, 2024 · Clustering analysis revealed 19 distinct clusters: adipocyte precursor cells (APCs), preadipocytes (pADs), smooth muscle cells (SMCs), endothelial cells (Endos), conventional type 1 DCs (cDC1s),... news in coventry